Evaluation of biomarker changes after administration of various neoadjuvant chemotherapies in breast cancer.

نویسندگان

  • Guangchao Jin
  • Yu Han
  • Cun Liu
  • Liansheng Chen
  • Butong Ding
  • Shijin Xuan
  • Xianqiang Liu
  • Guohui Ma
  • Jun Gao
  • Xingsong Tian
چکیده

To assess the changes in estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 expression in breast cancer patients after various neoadjuvant chemotherapies. Data from 138 locally advanced breast cancer patients with histological diagnoses were reviewed. Seventy patients (group 1) were given 4 cycles of 500 mg/m(2) cyclophosphamide and 50 mg/m(2) pirarubicin every 21 days. Sixty-eight patients (group 2) were given 4 cycles of 500 mg/m(2) cyclophosphamide and 75 mg/m(2) docetaxel every 21 days. The biomarker changes of the operated tumor tissues were compared with the initial core biopsies. ER, PR, HER2 and Ki-67 expression changed by 28.6%, 22.9%, 17.1% and 54.3%, respectively, after neoadjuvant chemotherapy in group 1 and 16.2%, 22.1%, 13.2% and 70.6%, respectively, after neoadjuvant chemotherapy in group 2. There were significant differences between the groups regarding ER and Ki-67 status changes, and these changes can be used to inform treatment strategies.

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عنوان ژورنال:
  • International journal of clinical and experimental pathology

دوره 8 1  شماره 

صفحات  -

تاریخ انتشار 2015